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Small-molecule inhibitors of your serine dipeptidases DPP8 and DPP9 (DPP8/nine) induce a lytic kind of cell Loss of life named pyroptosis in mouse and human monocytes and macrophages1,2. In mouse myeloid cells, Dpp8/9 inhibition activates the inflammasome sensor Nlrp1b, which subsequently activates Professional-caspase-one to mediate cell death3, t